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Comment
. 2003 Dec;10(12):1144-6.
doi: 10.1016/j.chembiol.2003.12.009.

CDK versus GSK-3 inhibition: a purple haze no longer?

Peter M Fischer  1
Affiliations
Comment

CDK versus GSK-3 inhibition: a purple haze no longer?

Peter M Fischer. Chem Biol. 2003 Dec.

Abstract

The ubiquitous ATP binding site offers a global target for protein kinase inhibitors. The corollary is that molecular selectivity with such agents may be difficult to achieve and ascertain. A relevant example is discussed in terms of design and biomedical rationale.

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  • GSK-3-selective inhibitors derived from Tyrian purple indirubins.
    Meijer L, Skaltsounis AL, Magiatis P, Polychronopoulos P, Knockaert M, Leost M, Ryan XP, Vonica CA, Brivanlou A, Dajani R, Crovace C, Tarricone C, Musacchio A, Roe SM, Pearl L, Greengard P. Meijer L, et al. Chem Biol. 2003 Dec;10(12):1255-66. doi: 10.1016/j.chembiol.2003.11.010. Chem Biol. 2003. PMID: 14700633

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