Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2004 Jan;113(1):25-7.
doi: 10.1172/JCI20660.

The relative roles of growth hormone and IGF-1 in controlling insulin sensitivity

David R Clemmons  1
Affiliations
Comment

The relative roles of growth hormone and IGF-1 in controlling insulin sensitivity

David R Clemmons. J Clin Invest. 2004 Jan.

Abstract

IGF-1 and growth hormone (GH) interact with insulin to modulate its control of carbohydrate metabolism. A new study (see the related article beginning on page 96) shows that blocking the effect of GH in the presence of low serum IGF-1 concentrations enhances insulin sensitivity.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Schematic diagram of insulin, GH, and IGF-1 regulation. IGFBP-3, IGF-binding protein-3; ALS, acid-labile subunit.
See this image and copyright information in PMC

Comment on

References

    1. Weaver JU, et al. The effect of low dose recombinant human growth hormone replacement on regional fat distribution, insulin sensitivity, and cardiovascular risk factors in hypopituitary adults. J. Clin. Endocrinol. Metab. 1995;80:153–159. - PubMed
    1. Yakar S, et al. Inhibition of growth hormone action improves insulin sensitivity in liver IGF-1–deficient mice. J. Clin. Invest. 2004;113:96–105. doi:10.1172/JCI200417763. - PMC - PubMed
    1. Tatar M, Bartke A, Antebi A. The endocrine regulation of aging by insulin-like signals. Science. 2003;299:1346–1351. - PubMed
    1. Isley WL, Underwood LE, Clemmons DR. Dietary components that regulate serum somatomedin-C in humans. J. Clin. Invest. 1983;71:175–182. - PMC - PubMed
    1. Rizza RA, Mandarino LJ, Gerich JE. Effects of growth hormone on insulin action in man. Mechanisms of insulin resistance, impaired suppression of glucose production, and impaired stimulation of glucose utilization. Diabetes. 1982;31:663–669. - PubMed