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Comment
. 2004 Jan;113(1):25-7.
doi: 10.1172/JCI20660.

The relative roles of growth hormone and IGF-1 in controlling insulin sensitivity

David R Clemmons  1
Affiliations
Comment

The relative roles of growth hormone and IGF-1 in controlling insulin sensitivity

David R Clemmons. J Clin Invest. 2004 Jan.

Abstract

IGF-1 and growth hormone (GH) interact with insulin to modulate its control of carbohydrate metabolism. A new study (see the related article beginning on page 96) shows that blocking the effect of GH in the presence of low serum IGF-1 concentrations enhances insulin sensitivity.

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Figures

Figure 1
Figure 1
Schematic diagram of insulin, GH, and IGF-1 regulation. IGFBP-3, IGF-binding protein-3; ALS, acid-labile subunit.
See this image and copyright information in PMC

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