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Case Reports
. 2003 Dec;78(5):439-42.
doi: 10.1007/BF02983817.

MLL/AF-1p fusion in therapy-related early pre-B acute lymphoblastic leukemia with t(1;11)(p32;q23) translocation developing in the relapse phase of acute promyelocytic leukemia

Takayuki Tsujioka  1 , Hideho Wada, Shunji Yamamori, Takemi Otsuki, Sinichiro Suemori, Toshinori Kondo, Hidekazu Nakanishi, Yoshimasa Suetsugu, Makoto Mikami, Takashi Sugihara
Affiliations
Case Reports

MLL/AF-1p fusion in therapy-related early pre-B acute lymphoblastic leukemia with t(1;11)(p32;q23) translocation developing in the relapse phase of acute promyelocytic leukemia

Takayuki Tsujioka et al. Int J Hematol. 2003 Dec.

Abstract

We report the development of therapy-related early pre-B acute lymphoblastic leukemia in a patient administered a topoisomerase II inhibitor, etoposide, a consolidation therapy agent for acute promyelocytic leukemia. Our case is of interest because of simultaneous relapse of the original leukemia and onset of therapy-related leukemia and relatively rare t(1;11)(p32;q23) translocation with confirmed MLL/AF-1p fusion. This case suggests that careful monitoring for MLL gene rearrangements is necessary after administration of topoisomerase II inhibitors.

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