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. 2004 Feb;10(2):155-60.
doi: 10.1038/nm977. Epub 2004 Jan 4.

PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide

Rolf Göggel  1 , Supandi Winoto-Morbach, Gabriele Vielhaber, Yumiko Imai, Karsten Lindner, Lore Brade, Helmut Brade, Stefan Ehlers, Arthur S Slutsky, Stefan Schütze, Erich Gulbins, Stefan Uhlig
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PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide

Rolf Göggel et al. Nat Med. 2004 Feb.

Abstract

Platelet-activating factor (PAF) induces pulmonary edema and has a key role in acute lung injury (ALI). Here we show that PAF induces pulmonary edema through two mechanisms: acid sphingomyelinase (ASM)-dependent production of ceramide, and activation of the cyclooxygenase pathway. Agents that interfere with PAF-induced ceramide synthesis, such as steroids or the xanthogenate D609, attenuate pulmonary edema formation induced by PAF, endotoxin or acid instillation. Our results identify acid sphingomyelinase and ceramide as possible therapeutic targets in acute lung injury.

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Comment in

  • Ceramide lances the lungs.
    Barnes PJ. Barnes PJ. Nat Med. 2004 Feb;10(2):130-1. doi: 10.1038/nm0204-130. Nat Med. 2004. PMID: 14760419 No abstract available.

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