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Review
. 2004 Feb;6(2):97-104.
doi: 10.1046/j.1462-5822.2003.00350.x.

The role of endosymbiotic Wolbachia bacteria in filarial disease

A G Hise  1 , I Gillette-Ferguson, E Pearlman
Affiliations
Review

The role of endosymbiotic Wolbachia bacteria in filarial disease

A G Hise et al. Cell Microbiol. 2004 Feb.

Abstract

In this review, we describe the pathogenic role of Wolbachia endosymbiotic bacteria in filarial diseases, focusing on the host innate immune responses to filarial and Wolbachia products. A description of the host pathogen recognition and early inflammatory responses including TLR4-mediated signalling, chemokine and cytokine responses and inflammatory cell recruitment is provided from human studies and from animal models of filarial disease. Finally, the impact of the discovery and characterization of Wolbachia on filarial research and treatment programmes is discussed.

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