Mediator modulation therapy of severe sepsis and septic shock: does it work?
- PMID: 14707593
- DOI: 10.1097/01.CCM.0000105423.06091.8E
Mediator modulation therapy of severe sepsis and septic shock: does it work?
Comment on
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Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002).Crit Care Med. 2004 Jan;32(1):1-12. doi: 10.1097/01.CCM.0000105118.66983.19. Crit Care Med. 2004. PMID: 14707554 Clinical Trial.
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Cardiovascular effects of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) in patients with septic shock: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002).Crit Care Med. 2004 Jan;32(1):13-20. doi: 10.1097/01.CCM.0000104209.07273.FC. Crit Care Med. 2004. PMID: 14707555 Clinical Trial.
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Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock.Crit Care Med. 2004 Jan;32(1):21-30. doi: 10.1097/01.CCM.0000105581.01815.C6. Crit Care Med. 2004. PMID: 14707556 Clinical Trial.
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