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Review
. 2004 Jan;5(1):23-32.
doi: 10.1038/nrm1279.

The GGA proteins: adaptors on the move

Juan S Bonifacino  1
Affiliations
Review

The GGA proteins: adaptors on the move

Juan S Bonifacino. Nat Rev Mol Cell Biol. 2004 Jan.

Abstract

The GGA proteins are a family of ubiquitously expressed, Arf-dependent clathrin adaptors that mediate the sorting of mannose-6-phosphate receptors between the trans-Golgi network and endosomes. Recent studies have elucidated the biochemical and structural bases for the interaction of the GGA proteins with many binding partners, and have shed light on the molecular and cellular mechanisms by which the GGA proteins participate in protein sorting.

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