Regulation of the c-Abl and Bcr-Abl tyrosine kinases
- PMID: 14708008
- DOI: 10.1038/nrm1280
Regulation of the c-Abl and Bcr-Abl tyrosine kinases
Abstract
The prototypic non-receptor tyrosine kinase c-Abl is implicated in various cellular processes. Its oncogenic counterpart, the Bcr-Abl fusion protein, causes certain human leukaemias. Recent insights into the structure and regulation of the c-Abl and Bcr-Abl tyrosine kinases have changed the way we look at these enzymes.
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