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Review
. 2004 Jan;5(1):33-44.
doi: 10.1038/nrm1280.

Regulation of the c-Abl and Bcr-Abl tyrosine kinases

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Review

Regulation of the c-Abl and Bcr-Abl tyrosine kinases

Oliver Hantschel et al. Nat Rev Mol Cell Biol. 2004 Jan.

Abstract

The prototypic non-receptor tyrosine kinase c-Abl is implicated in various cellular processes. Its oncogenic counterpart, the Bcr-Abl fusion protein, causes certain human leukaemias. Recent insights into the structure and regulation of the c-Abl and Bcr-Abl tyrosine kinases have changed the way we look at these enzymes.

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