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. 2004 Jan 14;126(1):187-93.
doi: 10.1021/ja037368r.

Schulzeines A-C, new alpha-glucosidase inhibitors from the marine sponge Penares schulzei

Kentaro Takada  1 , Taisuke Uehara, Yoichi Nakao, Shigeki Matsunaga, Rob W M van Soest, Nobuhiro Fusetani
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Schulzeines A-C, new alpha-glucosidase inhibitors from the marine sponge Penares schulzei

Kentaro Takada et al. J Am Chem Soc. .

Abstract

Three new alpha-glucosidase inhibitors, schulzeines A-C (1-3), were isolated from the marine sponge Penares schulzei. Their structures were elucidated by spectral analysis and chemical degradations to be the isoquinoline alkaloids, encompassing two amino acids, and C(28) fatty acid, the last of which was sulfated. Absolute stereochemistry of schulzeines was determined by application of the modified Mosher analysis to fragments obtained by chemical degradation. Schulzeines A-C inhibit alpha-glucosidase with IC(50) values of 48-170 nM.

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