The Sézary syndrome lymphoid cell: abnormal surface properties and mitogen responsiveness
- PMID: 147100
- DOI: 10.1111/j.1365-2141.1975.tb00890.x
The Sézary syndrome lymphoid cell: abnormal surface properties and mitogen responsiveness
Abstract
The peripheral blood lymphoid cells of five patients with Sézary syndrome (SS) were examined with respect to their surface membrane characteristics and their response to mitogens. These cells showed markedly defective mitogenic responses to a broad dose range of phytohaemagglutinin (PHA), pokeweed mitogen, concanavalin A, and a rabbit antihuman lymphocyte antiserum (ATS), when compared with normal human lymphocytes. SS lymphoid cells (three patients studied) also displayed diminished or nearly absent capacity to form rosettes with unsensitized sheep erythrocytes (E-rosettes), and lacked surface immunoglobulin determinants. Despite their poor mitogenic response to ATS, they were as susceptible as normal lymphocytes to ATS-induced, complement mediated cytotoxicity. By comparison with lymphocytes from patients with chronic lymphocytic leukaemia, however, SS lymphoid cells showed decreased susceptibility to leukoagglutination by PHA. By way of contrast, three patients with mycosis fungoides having normal-appearing peripheral blood lymphocytes showed normal lymphocyte responses to mitogens, as well as normal proportions of E-rosette forming and surface immunoglobulin-bearing lymphocytes. These studies demonstrate that the SS lymphoid cell may, in some cases, lack surface properties and mitogen response characteristics of both B- and T-lymphocytes.
Similar articles
-
Rosette-formation with mouse erythrocytes: VI. T, B, and third population lymphoid cells in mycosis fungoides and effect of leukopheresis.Am J Hematol. 1978;4(2):133-40. doi: 10.1002/ajh.2830040205. Am J Hematol. 1978. PMID: 150227
-
Ultrastructural, immunologic, and functional studies on Sézary cells: a neoplastic variant of thymus-derived (T) lymphocytes.Proc Natl Acad Sci U S A. 1974 May;71(5):1877-81. doi: 10.1073/pnas.71.5.1877. Proc Natl Acad Sci U S A. 1974. PMID: 4275944 Free PMC article.
-
T cell variant of chronic lymphocytic leukaemia with chromosome abnormality and defective response to mitogens.Br J Haematol. 1976 Aug;33(4):459-68. doi: 10.1111/j.1365-2141.1976.tb03564.x. Br J Haematol. 1976. PMID: 795454
-
Human peripheral blood lymphocytes. Isolation, subset characterization and in vitro properties. A review of the literature of the 1970s.Acta Pathol Microbiol Scand Suppl. 1981;277:1-38. Acta Pathol Microbiol Scand Suppl. 1981. PMID: 6462000 Review. No abstract available.
-
The rabbit immune system: characterization of cell surface markers and functional properties of rabbit lymphocytes.Mol Immunol. 1979 Dec;16(12):1045-58. doi: 10.1016/0161-5890(79)90038-5. Mol Immunol. 1979. PMID: 161609 Review. No abstract available.
Cited by
-
Demonstration of the inhibitory effect of human alpha-fetoprotein on in vitro transformation of human lymphocytes.Proc Natl Acad Sci U S A. 1976 Aug;73(8):2857-61. doi: 10.1073/pnas.73.8.2857. Proc Natl Acad Sci U S A. 1976. PMID: 60761 Free PMC article.
-
Diagnosis of cutaneous T cell lymphoma by use of monoclonal antibodies reactive with tumor-associated antigens.J Clin Invest. 1982 Dec;70(6):1205-15. doi: 10.1172/jci110719. J Clin Invest. 1982. PMID: 6217214 Free PMC article.
-
A case of small-cell Sézary's syndrome with null-cell features.J Clin Pathol. 1976 Sep;29(9):848-51. doi: 10.1136/jcp.29.9.848. J Clin Pathol. 1976. PMID: 135771 Free PMC article.
-
Evidence for the presence of a receptor for IgM on the pathological cells of Sézary's syndrome.Clin Exp Immunol. 1978 Mar;31(3):391-6. Clin Exp Immunol. 1978. PMID: 148985 Free PMC article.
-
T-cell nature of leukaemic cells in a case of Sézary's syndrome with 'null-cell' features.J Clin Pathol. 1979 Sep;32(9):912-7. doi: 10.1136/jcp.32.9.912. J Clin Pathol. 1979. PMID: 315966 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources