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. 2003 Oct;136(4):325-7.
doi: 10.1023/b:bebm.0000010942.14275.50.

Secretory activity of mast cell during stress: effect of prolyl-glycyl-proline and Semax

B A Umarova  1 , G N Kopylova, E A Smirnova, A A Guseva, S E Zhuikova
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Secretory activity of mast cell during stress: effect of prolyl-glycyl-proline and Semax

B A Umarova et al. Bull Exp Biol Med. 2003 Oct.

Abstract

Stress increased secretory activity of mast cells in the mesentery and subcutaneous fat of rats. Intraperitoneal injection of Semax and prolyl-glycyl-proline in doses of 0.05 and 1 mg/kg, respectively, 1 h before stress abolished this effect. The test preparations did not modulate secretory activity of mast cells in unstressed animals. Semax and prolyl-glycyl-proline in vitro prevented activation of mast cells with synacten and acetylcholine. The stabilizing effect of peptides on mast cells probably determines their antiulcer activity.

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