Analyzing factors affecting the success rate of frozen-thawed embryos
- PMID: 14714822
- PMCID: PMC3455644
- DOI: 10.1023/b:jarg.0000006705.46147.a2
Analyzing factors affecting the success rate of frozen-thawed embryos
Abstract
Purpose: In recent years the infertile population applying for IVF treatments was changed and so the indications for performing intracellular sperm injection (ICSI). The aim of this study was to analyze predicting factors of our thawing cycles.
Methods: From December 1998 to July 2001, 440 consecutive thawing cycles were performed. Patient characteristics were examined. The number of cryopreserved embryos, number of transferred embryos, the timing of cryopreservation (48 h vs. 72 h), and embryo survival rate were analyzed as a possible predictor for pregnancies achievement.
Results: Conventional IVF patient's characteristic was significantly different from ICSI population and analysis has been performed for every population separately. In the IVF population the women age, the number of transferred embryos, and timing of cryopreservation were factors significantly influencing the pregnancy rate. Interestingly, in the ICSI population only the number of transferred embryos was found to be a predictive factor.
Conclusion: ICSI and IVF cycles should be analyzed separately. Not all the factors influencing the success rate in the conventional IVF population are valid in the ICSI population.
Similar articles
-
Impairment of the developmental potential of frozen-thawed human zygotes obtained after intracytoplasmic sperm injection.Fertil Steril. 1998 Apr;69(4):630-5. doi: 10.1016/s0015-0282(98)00021-1. Fertil Steril. 1998. PMID: 9548150
-
Comparison of cryopreservation outcome following intracytoplasmic sperm injection and conventional in vitro fertilization.J Assist Reprod Genet. 1998 Aug;15(7):431-7. doi: 10.1007/BF02744937. J Assist Reprod Genet. 1998. PMID: 9717119 Free PMC article.
-
Potential factors affecting embryo survival and clinical outcome with cryopreserved pronuclear human embryos.Am J Obstet Gynecol. 2004 Jun;190(6):1766-71; discussion 1771-2. doi: 10.1016/j.ajog.2004.02.049. Am J Obstet Gynecol. 2004. PMID: 15284794
-
Cryopreservation of human embryos and its contribution to in vitro fertilization success rates.Fertil Steril. 2014 Jul;102(1):19-26. doi: 10.1016/j.fertnstert.2014.05.027. Epub 2014 Jun 2. Fertil Steril. 2014. PMID: 24890275 Review.
-
Single embryo transfer and IVF/ICSI outcome: a balanced appraisal.Hum Reprod Update. 2005 Mar-Apr;11(2):105-21. doi: 10.1093/humupd/dmh049. Epub 2004 Oct 28. Hum Reprod Update. 2005. PMID: 15514015 Review.
Cited by
-
Natural cycle versus artificial cycle in frozen-thawed embryo transfer: A randomized prospective trial.Turk J Obstet Gynecol. 2018 Mar;15(1):12-17. doi: 10.4274/tjod.47855. Epub 2018 Mar 29. Turk J Obstet Gynecol. 2018. PMID: 29662710 Free PMC article.
-
Effect of progesterone supplementation on natural frozen-thawed embryo transfer cycles: a randomized controlled trial.Int J Fertil Steril. 2013 Apr;7(1):13-20. Epub 2013 Mar 6. Int J Fertil Steril. 2013. PMID: 24520458 Free PMC article.
-
Correlation between embryological factors and pregnancy rate: development of an embryo score in a cryopreservation programme.J Assist Reprod Genet. 2011 Feb;28(2):129-36. doi: 10.1007/s10815-010-9498-0. Epub 2010 Nov 2. J Assist Reprod Genet. 2011. PMID: 21042843 Free PMC article.
-
The Effect of Uterine Contractions on Fertility Outcomes in Frozen Embryo Transfer Cycles: A Cohort Study.J Reprod Infertil. 2023 Apr-Jun;24(2):132-138. doi: 10.18502/jri.v24i2.12498. J Reprod Infertil. 2023. PMID: 37547572 Free PMC article.
-
A comparison of pregnancy rate between natural cycle and hormone replacement cycle in patients who underwent frozen embryo transfer using 2 consecutive hormone replacement regiments: A STROBE-compliant retrospective study.Medicine (Baltimore). 2020 Sep 11;99(37):e22163. doi: 10.1097/MD.0000000000022163. Medicine (Baltimore). 2020. PMID: 32925779 Free PMC article.
References
-
- Trounson A, Mohr L. Human pregnancy following cryopreservation, thawing and transfer of an eight-cell embryo. Nature. 1983;305:707–709. - PubMed
-
- Testart J, Lassalle B, Belaisch-Allart J, Hazout A, Forman R, Rainborn JD, Frydman R. High pregnancy rate after early human embryo freezing. Fertil Steril. 1986;46:268–272. - PubMed
-
- Camus M, Van Den Abbeel E, Van Waesberghe L, Wisanto A, Devroey P, Van Steirteghem AC. Human viability after freezing with dimethylsulfoxide as a cryoprotectant. Fertil Steril. 1989;51:460–465. - PubMed
-
- Van Der Elts J, Van Den Abbeel E, Vitrier S, Camus M, Devroey P, Van Steirteghem AC. Selective transfer of cryopreserved human embryos with further cleavage after thawing increases delivery and implantation rates. Hum Reprod. 1997;12:1513–1521. - PubMed
-
- Shapiro BS, Harris DC, Richter KS. Predictive value of 72-hour blastomere cell number on blastocyst development and success of subsequent transfer based on the degree of blastocyst development. Fertil Steril. 2000;73:582–586. - PubMed
MeSH terms
LinkOut - more resources
Full Text Sources
Medical