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Clinical Trial
. 2004 Jan 15;93(2):195-8.
doi: 10.1016/j.amjcard.2003.09.036.

Effect of abciximab on prothrombin activation and thrombin generation in patients with acute myocardial infarction also receiving reteplase

Piera Angelica Merlini  1 , Alessandra Repetto, Anna Maria Andreoli, Silvio Ricci, Alessandro Lombardi, Angelo Finardi, Giuseppe Dipasquale, Monica Lamponi, Pier Mannuccio Mannucci, Diego Ardissino
Affiliations
Clinical Trial

Effect of abciximab on prothrombin activation and thrombin generation in patients with acute myocardial infarction also receiving reteplase

Piera Angelica Merlini et al. Am J Cardiol. .

Abstract

Fibrinolysis in acute myocardial infarction activates blood coagulation and may favor reocclusion or ischemic complications. The aim of the GUSTO V Italian Hematologic Substudy was to compare the effects of full-dose reteplase on coagulation activation markers with those of half-dose reteplase combined with full-dose abciximab, a platelet glycoprotein IIb/IIIa receptor antagonist, during the early phase after acute myocardial infarction.

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