Efficacy of galactomannan antigen in the Platelia Aspergillus enzyme immunoassay for diagnosis of invasive aspergillosis in liver transplant recipients
- PMID: 14715799
- PMCID: PMC321718
- DOI: 10.1128/JCM.42.1.435-438.2004
Efficacy of galactomannan antigen in the Platelia Aspergillus enzyme immunoassay for diagnosis of invasive aspergillosis in liver transplant recipients
Abstract
The utility of galactomannan antigen for diagnosing invasive aspergillosis was evaluated in 154 liver transplant recipients. Sample agreement was 98.5%, and patient specificity was 87%. Galactomannan positivity correlated with mortality, even when controlled for the number of tests performed. Whether galactomannan positivity identifies a subgroup at risk for poor outcome warrants further evaluation.
References
-
- Ascioglu, S., J. H. Rex, J. E. Bennett, J. Billie, F. Croksert, D. W. Denning et. al. 2002. Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus. Clin. Infect. Dis. 34:7-14. - PubMed
-
- Bennett, J. E., M. M. Friedman, and B. Dupont. 1987. Receptor-mediated clearance of Aspergillus galactomannan. J. Infect. Dis. 155:1005-1010. - PubMed
-
- Hamaki, T., M. Kami, Y. Kanda, S. Miyakoshi, J. Ueyama, S. Morinaga, and Y. Mutou. 2001. False-positive results of Aspergillus enzyme-linked immunosorbent assay in a patient with chronic graft-versus-host disease after allogeneic bone marrow transplantation. Bone Marrow Transplant. 28:633-643. - PubMed
-
- Milkiewicz, P., B. Gunson, S. Saksena, M. Hathaway, S. Hubscher, and E. Elias. 2000. Increased incidence of chronic rejection in adult patients transplanted for autoimmune hepatitis: assessment of risk factors. Transplantation 70:477-480. - PubMed
-
- Paterson, D. L., and N. Singh. 1999. Invasive aspergillosis in transplant recipients. Medicine 78:123-138. - PubMed
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