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Review
. 2003 Dec:26 Suppl 7:11-6.
doi: 10.1159/000076168.

[Current status and perspectives of chemotherapy for anthracycline-pretreated breast cancer]

[Article in German]
Affiliations
Review

[Current status and perspectives of chemotherapy for anthracycline-pretreated breast cancer]

[Article in German]
V Heinemann. Onkologie. 2003 Dec.

Abstract

Randomized trials performed in anthracycline-pretreated breast cancer patients have demonstrated good activity of taxane-based regimens. In a face to face comparison, single-agent docetaxel proved to be significantly more effective than paclitaxel. Treatment with docetaxel was also associated with an increased incidence of grade grade-3/4 toxicities in this trial. Antitumor activity of taxane-based combination regimens was clearly superior to single-agent therapy in two trials. As anticipated, treatment-associated toxicity was greater with combination regimens, but this did not affect quality of life.

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