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Case Reports
. 2003 Nov;9(11):1455-7.
doi: 10.3201/eid0911.030317.

Fluoroquinolone resistance linked to GyrA, GyrB, and ParC mutations in Salmonella enterica typhimurium isolates in humans

Isabelle Casin  1 , Jacques Breuil, Jean Pierre Darchis, Claire Guelpa, Ekkehard Collatz
Affiliations
Case Reports

Fluoroquinolone resistance linked to GyrA, GyrB, and ParC mutations in Salmonella enterica typhimurium isolates in humans

Isabelle Casin et al. Emerg Infect Dis. 2003 Nov.

Abstract

We report two cases of infection with clonally unrelated, high-level ciprofloxacin-resistant, b-lactamase-producing strains of Salmonella enterica Typhimurium. Resistance was caused by four topoisomerase mutations, in GyrA, GyrB, and ParC and increased drug efflux. Ciprofloxacin treatment failed in one case. In the second case, reduced susceptibility to third-generation cephalosporins occurred after initial treatment with these drugs and may explain the treatment failure with ceftriaxone.

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