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Case Reports
. 2004 Jan;27(1):18-20.
doi: 10.1016/s0210-5705(03)70439-7.

[Indomethacin-induced ileal perforation]

[Article in Spanish]
R F Baldonedo Cernuda  1 , J A Alvarez Pérez, I García Bear, N Truán Alonso, J I Jorge Barreiro
Affiliations
Case Reports

[Indomethacin-induced ileal perforation]

[Article in Spanish]
R F Baldonedo Cernuda et al. Gastroenterol Hepatol. 2004 Jan.

Abstract

We present two cases of indomethacin-induced perforation of the distal small intestine. Both patients were male and undergoing oral indomethacin therapy. Both presented acute abdomen with diffuse peritonitis secondary to perforations located in the antimesenteric border of the terminal ileum. Histopathological lesions of the intestinal wall showed transmural infiltration, congestion, and hemorrhage; their severity was related to higher doses and longer duration of indomethacin therapy.

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