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Review
. 2004 Feb;11(2):401-5.

Apoptosis: escaping strategies in human skin cancer (Review)

Luca Giannetti  1 , Ugo Consolo, Cristina Magnoni, Lorenzo Lo Muzio
Affiliations
  • PMID: 14719075
Review

Apoptosis: escaping strategies in human skin cancer (Review)

Luca Giannetti et al. Oncol Rep. 2004 Feb.

Abstract

Apoptosis must be considered a rescue mechanism that controls the integrity of the cell erasing aberrant clones and it is likely that failure of apoptosis constitutes a key factor responsible for tumour formation, progression and resistance to drugs. Several genes (e.g. survivin, bcl-2 family, p53) are involved in these pathways. Much work still needs to be done to identify the molecular pathway of apoptosis resistance but restoration of the apoptotic response represents a crucial new therapeutic target for cancer treatment.

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