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. 1992 Dec 15;288 ( Pt 3)(Pt 3):713-6.
doi: 10.1042/bj2880713.

A red cell band 3 variant with altered stilbene disulphonate binding is associated with the Diego (Dia) blood group antigen

F A Spring  1 , L J Bruce, D J Anstee, M J Tanner
Affiliations

A red cell band 3 variant with altered stilbene disulphonate binding is associated with the Diego (Dia) blood group antigen

F A Spring et al. Biochem J. .

Abstract

1. We have shown that the Dia antigen of the Diego blood group system is associated with the presence of red cell band 3 Memphis, but not all band 3 Memphis samples carry the Dia antigen. 2. The band 3 Memphis associated with the Dia antigen was covalently labelled by 4,4'-di-isothiocyanato-1,2-diphenylethane-2,2'-disulphonic acid (H2DIDS) more readily than was normal band 3 or band 3 Memphis not associated with the Dia antigen. This altered reactivity with H2DIDS has previously been noted for a band 3 Memphis sub-type designated variant 2. 3. This is the first example of a band 3 polymorphism associated with an antigenic change in the extracellular region of the band 3 polypeptide and with altered H2DIDS binding.

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