[Synthesis of new pyrimidine 5'-H-thiophosphonates]
[Article in
Russian]
- PMID: 1472118
Item in Clipboard
[Synthesis of new pyrimidine 5'-H-thiophosphonates]
[Article in
Russian]
Bioorg Khim.
1992 Sep.
Abstract
Thymidine and 3'-deoxythymidine 5'-H-thiophosphonates were synthesized by interaction of 3'-O-acetylthymidine or 3'-deoxythymidine and ammonium phosphinate in the presence of pivaloyl chloride and following oxidation in situ by sulfur of the intermediate phosphinates. The compounds seemed to be 1:1 mixture of diastereomers with chiral phosphorus. The prepared compounds were tested as potential inhibitors of HIV production.
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