Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2004 Jan;113(2):182-4.
doi: 10.1172/JCI20846.

Bateman domains and adenosine derivatives form a binding contract

Bruce E Kemp  1
Affiliations
Review

Bateman domains and adenosine derivatives form a binding contract

Bruce E Kemp. J Clin Invest. 2004 Jan.

Abstract

Conserved pairs of CBS sequence motifs (named after cystathionine beta-synthase) found in a wide variety of proteins associate to form Bateman domains. A new study establishes that Bateman domains bind adenosyl compounds and regulate IMP dehydrogenase, CBS, chloride channels, and AMP-activated protein kinase. This discovery reveals how mutations in CBS sequences in these proteins cause hereditary diseases and provides a rich vista of conceptual opportunities for therapies in energy metabolism, obesity, diabetes, cancer, antivirals, and immunosuppression.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Pairs of CBS sequences within a protein fold into Bateman domains that bind adenosyl compounds and that mediate the allosteric control of their parent proteins. Shown is the surface-modeled Bateman domain formed by the CBS-1 and CBS-2 sequences of the AMPK γ1 subunit with AMP present in the central binding pocket (4). AdoMet, S-adenosyl methionine.
See this image and copyright information in PMC

Comment on

References

    1. The CBS domain web page. The Sanger Institute. http://www.sanger.ac.uk/Users/agb/CBS/CBS.html.
    1. Bateman A. The structure of a domain common to archaebacteria and the homocystinuria disease protein. Trends Biochem. Sci. 1997;22:12–13. - PubMed
    1. Zhang R, et al. Characteristics and crystal structure of bacterial inosine-5′-monophosphate dehydrogenase. Biochemistry. 1999;38:4691–4700. - PubMed
    1. Adams, J., et al. 2004. Intrasteric control of AMPK via the gamma-1 subunit AMP allosteric regulatory site. Protein Sci. In press. - PMC - PubMed
    1. Kluijtmans LA, et al. Defective cystathionine beta-synthase regulation by S-adenosylmethionine in a partially pyridoxine responsive homocystinuria patient. J. Clin. Invest. 1996;98:285–289. - PMC - PubMed