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Review
. 2004 Jan;77(1):363-71.
doi: 10.1016/j.athoracsur.2003.07.007.

Drug immunosuppression therapy for adult heart transplantation. Part 2: clinical applications and results

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Review

Drug immunosuppression therapy for adult heart transplantation. Part 2: clinical applications and results

Xavier M Mueller. Ann Thorac Surg. 2004 Jan.

Abstract

This review describes the clinical application of classical immunosuppressive drugs as well as that of more recent drugs. All current immunosuppressive drugs target T-cell activation, and cytokine production and clonal expansion, or both. Immunosuppressive protocols can be broadly divided into induction therapy, maintenance immunosuppression, and treatment of acute rejection episodes.

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