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Comparative Study
. 2004 Mar;49(3):249-52.
doi: 10.1016/j.phrs.2003.10.004.

Effect of vitamins C and E on cognitive function in mouse

A Arzi  1 , A A Hemmati, A Razian
Affiliations
Comparative Study

Effect of vitamins C and E on cognitive function in mouse

A Arzi et al. Pharmacol Res. 2004 Mar.

Abstract

The aim of this study was to verify the role of Vitamins C and E on the cognitive function of young and aged mice. First and second groups of young animals (aged 3 months) received either Vitamin E (250mg/kg per day) or Vitamin C (300mg/kg per day) for 60 days. Third group was treated with the combination of Vitamin E (250mg/kg per day) and Vitamin C (300mg/kg per day) for 60 days. The control group received only vehicle. The aged animal group (aged 15 months) were treated as the young group. Passive avoidance method was used for the assessment of cognitive function in both young and aged animals. The results indicated a significant improvement in the cognitive function of aged mice while there were no significant changes in young animals.

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