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. 2004 Mar;3(3):265-6.
doi: 10.4161/cc.3.3.722. Epub 2004 Mar 1.

APC activators caught by their tails?

Hartmut C Vodermaier  1 , Jan-Michael Peters
Affiliations

APC activators caught by their tails?

Hartmut C Vodermaier et al. Cell Cycle. 2004 Mar.

Abstract

The complexity of the Anaphase-Promoting Complex (APC), the major ubiquitin ligase in mitotic control, has been puzzling investigators ever since its discovery. Recent biochemical and genetic studies have now provided insights not only into the architecture of the complex, but also into how activators are recruited to the APC. In this article, we discuss the implications of these findings on our current understanding of APC activation.

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