Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2003:2003:445-9.

Expression array annotation using the BioMediator biological data integration system and the BioConductor analytic platform

Affiliations

Expression array annotation using the BioMediator biological data integration system and the BioConductor analytic platform

H Mei et al. AMIA Annu Symp Proc. 2003.

Abstract

This paper presents the implementation of a model for expression array annotation (EAA) using the BioMediator biological data integration system along with BioConductor, an analytic tools platform. The model presented addresses the need for annotation sources identified during BioConductor inverted exclamation mark s development. Annotation provides us with well-curated genomic background knowledge for expression array analysis and interpretation. Annotation requests are constructed and posted to the query interface of the EAA package (the EAA model implemented as a component of BioConductor). The software enumerates all possible annotation paths for queries. These are then transformed to PQL queries and processed by BioMediator. Annotation entities returned from the EAA package answer the annotation request.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Expression Array Annotation (EAA) Model Bridge Bioconductor and Biomediator
Figure 2
Figure 2
Searching Schema

References

    1. Brown MPS, Grundy WN, Lin D, et al. Knowledge-based analysis of microarray gene expression data using support vector machines. Proceedings of the National Academy of Sciences. 1999;97(1):262–267. - PMC - PubMed
    1. Gene Ontology Consortium (GO). Gene ontology (go). http://www.geneontology.org/
    1. Hvidsten TR, Komorowski J, Sandvik AK, Laegreid A. Predicting gene function from gene expressions and ontologies. In: Pacific Symposium on Biocomputing; 2001; 2001. p. 299–310. - PubMed
    1. Dettling M, Buhlmann P. Supervised clustering of genes. Genome Biology. 2002;3(12):1–15. - PMC - PubMed
    1. Bioconductor. http://www.bioconductor.org/

Publication types

MeSH terms

LinkOut - more resources