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. 1992 Sep;2(9):268-71.
doi: 10.1016/0962-8924(92)90199-w.

T-cell activation

M Izquierdo  1 , D A Cantrell
Affiliations

T-cell activation

M Izquierdo et al. Trends Cell Biol. 1992 Sep.

Abstract

Activation of T lymphocytes results in immediate intracellular biochemical changes, including increases in cytosolic Ca(2+) levels, stimulation of protein kinase C (PKC) and regulation of protein tyrosine kinases (PTKs). This review describes recent advances in the study of the signalling steps downstream of PKC and PTKs in T cells. A model is presented in which the GTP-binding protein p21(ras) acts as an integrator of the signal transduction pathways controlled by the T-cell antigen receptor.

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