Is plasma membrane lipid composition defined in the exocytic or the endocytic pathway?
- PMID: 14731621
- DOI: 10.1016/0962-8924(94)90076-0
Is plasma membrane lipid composition defined in the exocytic or the endocytic pathway?
Abstract
Compared with intracellular membranes, the plasma membrane is rich in cholesterol and sphingomyelin. How does this distinct composition arise? Here David Allan and Karl-Josef Kallen take a critical view of the belief that these lipids arrive at the plasma membrane via vesicular traffic from the Golgi complex and propose instead that they may be accreted in the endocytic recycling pathway.
Comment in
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Sphingomyelin synthesis in endosomal compartments?Trends Cell Biol. 1995 Apr;5(4):148-9; author reply 149. doi: 10.1016/s0962-8924(00)88969-2. Trends Cell Biol. 1995. PMID: 14732140 No abstract available.
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