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. 1992 Jan;2(1):10-4.
doi: 10.1016/0962-8924(92)90138-d.

Telomeric position effect in yeast

L L Sandell  1 , V A Zakian
Affiliations

Telomeric position effect in yeast

L L Sandell et al. Trends Cell Biol. 1992 Jan.

Abstract

Telomeres are the physical ends of chromosomes. In yeast, when a gene is placed near a telomere, its transcription is repressed. Genes under the influence of this telomeric position effects switch between a repressed state and a transcriptionally active state, each of which is stable for many cell generations. Telomeric position effect may provide a model system for the study of heritable gene regulation in other, more complex organisms.

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