Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1994 May;4(5):152-4.
doi: 10.1016/0962-8924(94)90190-2.

Calreticulin: from Ca2+ binding to control of gene expression

K Burns  1 , E A Atkinson, R C Bleackley, M Michalak
Affiliations

Calreticulin: from Ca2+ binding to control of gene expression

K Burns et al. Trends Cell Biol. 1994 May.

Abstract

Calreticulin is a highly conserved Ca(2+)-binding/storage protein of the endoplasmic reticulum (ER). Recently, it has been shown to play a role in the control of gene expression by interacting with the DNA-binding domain of various steroid receptors. How does this ER protein gain access to the nuclear steroid receptors? We propose that calreticulin undergoes unique intracellular trafficking that allows it to colocalize with and bind to steroid receptors.

PubMed Disclaimer

LinkOut - more resources