Anterograde transport through the Golgi complex: do Golgi tubules hold the key?

Abstract

Biochemical studies have suggested that anterograde protein transport through the Golgi complex is mediated by coatomer-coated vesicles that bud from one compartment and then transfer to, and fuse with, the next. However, recent genetic studies have shown that coatomer mutations block retrograde, but not anterograde, transport in yeast, calling into question the role of coatomer vesicles in anterograde transport. Peggy Weidman proposes that these findings might be explained if anterograde transport occurs by transient fusion of Golgi tubules and if coatomers have related, but separable, functions in tubule and vesicle dynamics.