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. 1995 Mar;5(3):133-7.
doi: 10.1016/s0962-8924(00)88965-5.

Lysosome recruitment during host cell invasion by Trypanosoma cruzi

N W Andrews  1
Affiliations

Lysosome recruitment during host cell invasion by Trypanosoma cruzi

N W Andrews. Trends Cell Biol. 1995 Mar.

Abstract

The protozoan parasite Trypanosoma cruzi uses an unusual mechanism to enter cells. Recent observations revealed that instead of trypanosomes being brought in to fuse with lysosomes, it is the lysosomes that migrate to the trypanosomes and actually participate in their internalization. Signalling events involving intracellular free Ca2+ occur upon contact of the parasites with host cells and may contribute to the regulation of this unusual process.

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