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. 2004 Jan;23(1):88-91.
doi: 10.1016/j.ijantimicag.2003.06.004.

Low in vitro selection frequencies of enterococcal and staphylococcal mutants resistant to the oxazolidinone AZD2563

Mark W Stockdale  1 , Luke Tysall, Alan P Johnson, David M Livermore, Neil Woodford
Affiliations

Low in vitro selection frequencies of enterococcal and staphylococcal mutants resistant to the oxazolidinone AZD2563

Mark W Stockdale et al. Int J Antimicrob Agents. 2004 Jan.

Abstract

Mutants with oxazolidinone MICs, 2- to 16-fold higher than those of parents, were selected from two of five clinical isolates of Enterococcus faecalis during exposure to AZD2563, but only at frequencies of ca. 10(-8). Resistance was not selected in Enterococcus faecium, Staphylococcus aureus or coagulase-negative staphylococci (CoNS). Mutants of one E. faecalis isolate had a G2576-->U 23S rRNA mutation; mutants derived from the second E. faecalis isolate lacked this mutation.

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