doi: 10.1016/0165-3806(92)90113-b.
Chronic prenatal morphine treatment decreases G alpha s mRNA levels in neonatal frontal cortex
Affiliations
- PMID: 1473274
- DOI: 10.1016/0165-3806(92)90113-b
Item in Clipboard
Chronic prenatal morphine treatment decreases G alpha s mRNA levels in neonatal frontal cortex
Brain Res Dev Brain Res.
.
Abstract
G alpha s mRNA levels were measured in brain regions of newborn pups following prenatal morphine treatment. A significant decrease (24%) in G alpha s mRNA levels was observed in the frontal cortex. No changes were observed in other regions. This report demonstrates the first in vivo study of opiate effects on G-protein gene expression in neonates. The development of tolerance in vivo may involve complex interactions between several neurotransmitter systems having opposing actions on the G-protein system.
Similar articles
-
Morphine-induced reciprocal alterations in G alpha s and opioid peptide mRNA levels in discrete brain regions.J Neurosci Res. 1993 Dec 1;36(5):551-7. doi: 10.1002/jnr.490360507. J Neurosci Res. 1993. PMID: 7908338
-
In situ hybridization reveals specific increases in G alpha s and G alpha o mRNA in discrete brain regions of morphine-tolerant rats.Eur J Pharmacol. 1993 Feb 15;244(3):211-22. doi: 10.1016/0922-4106(93)90146-z. Eur J Pharmacol. 1993. PMID: 8458398
-
Consequences of prenatal morphine exposure on the hypothalamo-pituitary-adrenal axis in the newborn rat: effect of maternal adrenalectomy.J Neuroendocrinol. 1998 May;10(5):331-42. J Neuroendocrinol. 1998. PMID: 9663647
-
Increased density of guanine nucleotide-binding proteins in the postmortem brains of heroin addicts.Arch Gen Psychiatry. 1994 Jun;51(6):494-501. doi: 10.1001/archpsyc.1994.03950060058006. Arch Gen Psychiatry. 1994. PMID: 8192552
-
Reflections on: "A general role for adaptations in G-Proteins and the cyclic AMP system in mediating the chronic actions of morphine and cocaine on neuronal function".Brain Res. 2016 Aug 15;1645:71-4. doi: 10.1016/j.brainres.2015.12.039. Epub 2015 Dec 29. Brain Res. 2016. PMID: 26740398 Free PMC article. Review.
Cited by
-
Modeling prenatal opioid exposure in animals: Current findings and future directions.Front Neuroendocrinol. 2018 Oct;51:1-13. doi: 10.1016/j.yfrne.2017.09.001. Epub 2017 Sep 28. Front Neuroendocrinol. 2018. PMID: 28965857 Free PMC article. Review.
-
Enhancement of tolerance development to morphine in rats prenatally exposed to morphine, methadone, and buprenorphine.J Biomed Sci. 2010 Jun 7;17(1):46. doi: 10.1186/1423-0127-17-46. J Biomed Sci. 2010. PMID: 20529288 Free PMC article.
-
Anatomic distribution of apoptosis in medulla oblongata of infants and adults.J Anat. 2008 Feb;212(2):106-13. doi: 10.1111/j.1469-7580.2007.00842.x. Epub 2007 Dec 10. J Anat. 2008. PMID: 18069990 Free PMC article.
-
Consequences of Parental Opioid Exposure on Neurophysiology, Behavior, and Health in the Next Generations.Cold Spring Harb Perspect Med. 2021 Oct 1;11(10):a040436. doi: 10.1101/cshperspect.a040436. Cold Spring Harb Perspect Med. 2021. PMID: 32601130 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
