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Comparative Study
. 1992 Nov 2;227(3):353-6.
doi: 10.1016/0922-4106(92)90016-o.

Nucleotide sequence of estrogen receptor cDNA from Sprague-Dawley rat

E Spreafico  1 , E Bettini, G Pollio, A Maggi
Affiliations
Comparative Study

Nucleotide sequence of estrogen receptor cDNA from Sprague-Dawley rat

E Spreafico et al. Eur J Pharmacol. .

Abstract

The cDNA of the Sprague-Dawley rat estrogen receptor was sequenced. With respect to the published Wistar rat estrogen receptor sequence, a single amino acid difference (tryptophan instead of asparagine) was found in the hormone binding site. Since tryptophan was found at the same position in chicken, human and mouse estrogen receptors, it is proposed that the Wistar rat could represent an interesting natural mutant for estrogen receptor studies.

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