Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1992 Dec 1;48(11-12):1133-4.
doi: 10.1007/BF01948006.

L-threo-3,4-dihydroxyphenylserine, a noradrenaline precursor, inhibits dopamine release and metabolism in the rat striatum in vivo

K Mizoguchi  1 , M Tanaka, H Yokoo, M Yoshida, A Tsuda
Affiliations

L-threo-3,4-dihydroxyphenylserine, a noradrenaline precursor, inhibits dopamine release and metabolism in the rat striatum in vivo

K Mizoguchi et al. Experientia. .

Abstract

The effect of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) on dopamine (DA) release and metabolism in the striatum was studied in freely moving rats by intracerebral microdialysis techniques. The DA level as well as the levels of 3,4-dihydroxyphenylacetic acid and homovanillic acid were significantly decreased 140 min after the administration of L-threo-DOPS (50 mg/kg intraperitoneally). The results suggest that L-threo-DOPS inhibits the release and metabolism of DA in the striatum.

PubMed Disclaimer

References

    1. J Neurochem. 1980 May;34(5):1175-83 - PubMed
    1. Neurosci Lett. 1977 Mar;4(3-4):127-34 - PubMed
    1. Science. 1970 May 15;168(3933):849-50 - PubMed
    1. Life Sci. 1987 Oct 12;41(15):1763-76 - PubMed
    1. Brain Res. 1990 Dec 17;536(1-2):305-8 - PubMed