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. 2004 Jan 7:(1):124-5.
doi: 10.1039/b312129a. Epub 2003 Nov 21.

Novel and efficient synthesis of difficult sequence-containing peptides through O-N intramolecular acyl migration reaction of O-acyl isopeptides

Youhei Sohma  1 , Masato Sasaki, Yoshio Hayashi, Tooru Kimura, Yoshiaki Kiso
Affiliations

Novel and efficient synthesis of difficult sequence-containing peptides through O-N intramolecular acyl migration reaction of O-acyl isopeptides

Youhei Sohma et al. Chem Commun (Camb). .

Abstract

A novel and efficient method for the synthesis of difficult sequence-containing peptides has been developed based on the synthesis of O-acyl isopeptides followed by an O-N intramolecular acyl migration reaction, resulting in a remarkable improvement of the yields.

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