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. 2004 Feb 1;12(3):571-6.
doi: 10.1016/j.bmc.2003.11.001.

In vitro study of some medicinally important Mannich bases derived from antitubercular agent

Sheela Joshi  1 , Navita Khosla, Prapti Tiwari
Affiliations

In vitro study of some medicinally important Mannich bases derived from antitubercular agent

Sheela Joshi et al. Bioorg Med Chem. .

Abstract

Biologically active Mannich bases with heteroaromatic ring system have been synthesised employing Mannich reaction of isonicotinyl hydrazide with various sulphonamides/secondary amines. They were analysed by elemental analysis and characterized by uv, ir, 1H nmr spectroscopic studies. The Mannich bases were screened for their antibacterial activity against various gram positive and gram negative bacteria and were analyzed statistically. The results have shown that the compounds are quiet active against pathogens under study and were nontoxic.

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