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. 2004 Feb;48(2):641-3.
doi: 10.1128/AAC.48.2.641-643.2004.

Safety and efficacy of antimicrobial peptides against naturally acquired leishmaniasis

J Alberola  1 , A Rodríguez, O Francino, X Roura, L Rivas, D Andreu
Affiliations

Safety and efficacy of antimicrobial peptides against naturally acquired leishmaniasis

J Alberola et al. Antimicrob Agents Chemother. 2004 Feb.

Abstract

Leishmaniases, which are important causes of morbidity and mortality in humans and dogs, are extremely difficult to treat. Antimicrobial peptides are rarely used as alternative treatments for naturally acquired parasitic diseases. Here we report that the acylated synthetic antimicrobial peptide Oct-CA(1-7)M(2-9) is safe and effective for treating naturally acquired canine leishmaniasis.

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Figures

FIG. 1.
FIG. 1.
Relative L. infantum parasitemia after three doses of the acylated cecropin-melittin hybrid AP Oct-CA(1-7)M(2-9). The doses were administered on days 0, 2, and 4. Geometric mean and standard error of the mean (broken line) are shown.
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