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Review
. 2004 Sep;19(5):401-13.
doi: 10.1007/s00384-003-0563-3. Epub 2004 Jan 24.

Microarray-based gene expression profiling in pancreatic ductal carcinoma: status quo and perspectives

Robert Grützmann  1 , Hans Detlev Saeger, Jutta Lüttges, Hans Konrad Schackert, Holger Kalthoff, Günter Klöppel, Christian Pilarsky
Affiliations
Review

Microarray-based gene expression profiling in pancreatic ductal carcinoma: status quo and perspectives

Robert Grützmann et al. Int J Colorectal Dis. 2004 Sep.

Abstract

Background: Pancreatic ductal adenocarcinoma has an extremely poor prognosis. To improve the prognosis, novel molecular markers and targets for earlier diagnosis and adjuvant and/or neoadjuvant treatment need to be identified. One of the key techniques that has been developed to achieve this goal is DNA microarray profiling, which is used to identify the mechanisms of deregulated molecular functions in pancreatic carcinoma cells.

Objective: As several studies using microarrays have already been published, this review attempts to compare published data and crossvalidate the results. In addition, the applied techniques are discussed.

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References

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