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. 2004 Feb 5;6(3):337-40.
doi: 10.1021/ol0361249.

Citrafungins A and B, two new fungal metabolite inhibitors of GGTase I with antifungal activity

Sheo B Singh  1 , Deborah L Zink, George A Doss, Jon D Polishook, Carolyn Ruby, Elizabeth Register, Theresa M Kelly, Cynthia Bonfiglio, Joanne M Williamson, Rosemarie Kelly
Affiliations

Citrafungins A and B, two new fungal metabolite inhibitors of GGTase I with antifungal activity

Sheo B Singh et al. Org Lett. .

Abstract

[structure: see text] Screening of natural products extracts led to the discovery of citrafungins A and B, two new fungal metabolites of the alkylcitrate family that are inhibitors of GGTase I of various pathogenic fungal species with IC(50) values of 2.5-15 microM. These compounds exhibited antifungal activities with MIC values of 0.40-55 microM. The isolation, structure elucidation, relative and absolute stereochemistry, and biological activities of citrafungins are described.

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