Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2003 Dec 4;4(1):14.
doi: 10.1186/1465-9921-4-14. Print 2003.

Association studies for asthma and atopic diseases: a comprehensive review of the literature

Sabine Hoffjan  1 , Dan Nicolae, Carole Ober
Affiliations
Review

Association studies for asthma and atopic diseases: a comprehensive review of the literature

Sabine Hoffjan et al. Respir Res. .

Abstract

Hundreds of genetic association studies on asthma-related phenotypes have been conducted in different populations. To date, variants in 64 genes have been reported to be associated with asthma or related traits in at least one study. Of these, 33 associations were replicated in a second study, 9 associations were not replicated either in a second study or a second sample in the same study, and 22 associations were reported in just a single published study. These results suggest the potential for a great amount of heterogeneity underlying asthma. However, many of these studies are methodologically limited and their interpretation hampered by small sample sizes.

PubMed Disclaimer

References

    1. Cookson WO. Asthma genetics. Chest. 2002;121:7S–13S. - PubMed
    1. Hakonarson H, Wjst M. Current concepts on the genetics of asthma. Curr Opin Pediatr. 2001;13:267–277. - PubMed
    1. Hoffjan S, Ober C. Present status on the genetic studies of asthma. Curr Opin Immunol. 2002;14:709–717. - PubMed
    1. Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science. 1996;273:1516–1517. - PubMed
    1. Weiss ST. Association studies in asthma genetics. Am J Respir Crit Care Med. 2001;164:2014–2015. - PubMed

Publication types