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Review
. 2004 May;5(3):151-7.
doi: 10.1038/sj.gene.6364045.

A review of the MHC genetics of rheumatoid arthritis

J L Newton  1 , S M J Harney, B P Wordsworth, M A Brown
Affiliations
Review

A review of the MHC genetics of rheumatoid arthritis

J L Newton et al. Genes Immun. 2004 May.

Abstract

Rheumatoid arthritis is a common complex genetic disease, and, despite a significant genetic element, no gene other than HLA-DRB1 has been clearly demonstrated to be involved in the disease. However, this association accounts for less than half the overall genetic susceptibility. Investigation of other candidate genes, in particular those that reside within the major histocompatibility complex, are hampered by the presence of strong linkage disequilibrium and problems with study design.

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