doi: 10.1016/j.pbb.2003.12.003.
Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis
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- PMID: 14751470
- DOI: 10.1016/j.pbb.2003.12.003
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Sedative and sleep-enhancing properties of linarin, a flavonoid-isolated from Valeriana officinalis
Pharmacol Biochem Behav.
2004 Feb.
Abstract
We have recently reported the presence of the anxiolytic flavone 6-methylapigenin (MA) and of the sedative and sleep-enhancing flavanone glycoside 2S (-) hesperidin (HN) in Valeriana officinalis and Valeriana wallichii. MA, in turn, was able to potentiate the sleep-inducing properties of HN. The present paper reports the identification in V. officinalis of the flavone glycoside linarin (LN) and the discovery that it has, like HN, sedative and sleep-enhancing properties that are potentiated by simultaneous administration of valerenic acid (VA). These effects should be taken into account when considering the pharmacological actions of valeriana extracts.
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