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Comment
. 2004 Feb;5(2):140-1.
doi: 10.1038/sj.embor.7400080.

Finding needles in a haystack. In silico identification of eukaryotic selenoprotein genes

Donna M Driscoll  1 , Laurent Chavatte
Affiliations
Comment

Finding needles in a haystack. In silico identification of eukaryotic selenoprotein genes

Donna M Driscoll et al. EMBO Rep. 2004 Feb.

Abstract

In silico identification of eukaryotic selenoprotein genes

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Figures

Figure 1
Figure 1
Eukaryotic selenoprotein genes identified so far. Selenoprotein messenger RNAs (mRNAs) harbour a Sec-insertion sequence (SECIS) element in their 3′ untranslated region that triggers the recoding of the UGA codon into Sec (the location of which is shown in the coding sequence by a white bar). Deviations from the canonical SECIS are shown in bold. The taxon-specific distributions of some selenoproteins are indicated as follows: glutathione peroxidase 6 (GPx6; yellow) is found in humans and pigs, but not in rodents (Kryukov et al, 2003); methionines-sulphoxide reductase A (MsrA; green) is found only in the green alga Chlamydomonas reinhardtii (Novoselov et al, 2002); selenoprotein U (SelU) (red) is found in fish, chickens, sea urchins, a green alga and a diatom (Castellano et al, 2004), but not in higher eukaryotes. DI, iodothyronine deiodinase; TR, thioredoxin reductase.
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Comment on

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