[Alternative pathways for the activation of the renin-angiotensin system]

Abstract

The knowledge of the structure and function of the components of the renin-angiotensin system (RAS) is rapidly increasing. The classic pathway of angiotensin (Ang) II generation includes a reaction catalyzed by angiotensin-converting enzyme (ACE). We actually discuss the alternative pathways for the generation of Ang-II and other angiotensin peptides (Ang III, Ang IV, Ang (1-9), Ang (1-7), des-Asp-Ang I) and the responsible enzymes (tonins, cathepsins, chymases, aminopeptidases, dipeptidyl aminopeptidases, neutral endopeptidases, carboxypeptidases, ACE2 etc.). The development of novel enzyme inhibitors (e.g., nafamostat, sampatrilat) for more efficacious suppression of RAS activity is also considered.