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Comparative Study
. 2004 Feb 6;485(1-3):329-32.
doi: 10.1016/j.ejphar.2003.11.048.

Antitussive activity of the tachykinin NK1 receptor antagonist, CP-99994, in dogs

Richard W Chapman  1 , Aileen House, Fei Liu, Chander Celly, Hong Mei, John A Hey
Affiliations
Comparative Study

Antitussive activity of the tachykinin NK1 receptor antagonist, CP-99994, in dogs

Richard W Chapman et al. Eur J Pharmacol. .

Abstract

CP-99994 [(+)-(2S,3S)-3-(2-methoxybenzylamino)-2-phenylpiperidine] is a selective tachykinin NK(1) receptor antagonist that inhibits cough in guinea pigs and cats. This study examined the antitussive effects of CP-99994 in dogs produced by mechanical stimulation of the intrathoracic trachea. CP-99994 (10 mg/kg, p.o.) inhibited cough frequency by 52% at 2 h, 31% at 6 h and by 21% at 24 h. Cough amplitude was inhibited by 45% at 6 h but unchanged at 2 and 24 h after CP-99994. Plasma levels of CP-99994 were highest at 2 h (75+/-26 ng/ml) and fell to 22+/-6 ng/ml at 6 h. These results demonstrate antitussive activity of CP-99994 in dogs at a dose proven to antagonize tachykinin NK(1) receptors in this species.

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