Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2002;19(7-9):583-91.
doi: 10.1023/B:GLYC.0000014089.17121.cc.

Seeing strangers or announcing "danger": galectin-3 in two models of innate immunity

Sachiko Sato  1 , Julie Nieminen
Affiliations
Review

Seeing strangers or announcing "danger": galectin-3 in two models of innate immunity

Sachiko Sato et al. Glycoconj J. 2002.

Abstract

Recent investigations on the molecular mechanisms by which our immune system recognizes infections and initiates defense against those infections have led to the proposition of two models explaining the way our innate immunity system functions; the self-nonself model and the Danger model. In this review, the roles of galectin-3 in innate immunity against infections--host-pathogen interactions--will be discussed. We will shed light on the potential contribution of a beta-galactoside binding mammalian lectin, galectin-3 as a molecule implicated in innate immunity from the angle of both the self-nonself model and the Danger model.

PubMed Disclaimer

References

    1. J Immunol. 1998 Jul 1;161(1):385-9 - PubMed
    1. Immunobiology. 1997 Jun;197(1):97-109 - PubMed
    1. Semin Immunol. 1998 Oct;10(5):399-415 - PubMed
    1. J Exp Med. 1998 Mar 2;187(5):813-8 - PubMed
    1. Biochimie. 2001 Jul;83(7):667-76 - PubMed

Publication types

LinkOut - more resources