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Review
. 2004 Feb;186(4):895-902.
doi: 10.1128/JB.186.4.895-902.2004.

Sigma factors and global gene regulation in Mycobacterium tuberculosis

Affiliations
Review

Sigma factors and global gene regulation in Mycobacterium tuberculosis

Riccardo Manganelli et al. J Bacteriol. 2004 Feb.

Erratum in

  • J Bacteriol. 2004 Apr;186(8):2516. Proveddi, Roberta [corrected to Provvedi, Roberta]
No abstract available

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Figures

FIG. 1.
FIG. 1.
σ factor regulatory network. Arrows indicate the transcriptional relationships among σ factors. sigB can be transcribed by an RNAP containing σH, σE, or σL, depending on the environmental conditions. σH also promotes the transcription of its own structural gene and the induction of sigE after oxidative stress. The environmental signal activating σL is not known.

References

    1. Ades, S. E., I. L. Grigorovna, and C. A. Gross. 2003. Regulation of the alternative sigma factor σE during initiation, adaptation, and shutoff of the extracytoplasmic heat shock response in Escherichia coli. J. Bacteriol. 185:2512-2519. - PMC - PubMed
    1. Akaki, T., H. Tomioka, T. Shimizu, S. Dekio, and K. Sato. 2000. Comparative roles of free fatty acids with reactive nitrogen intermediates and reactive oxygen intermediates in expression of the anti-microbial activity of macrophages against Mycobacterium tuberculosis. Clin. Exp. Immunol. 121:302-310. - PMC - PubMed
    1. Av-Gay, Y., and M. Everett. 2000. The eukaryotic-like Ser/Thr protein kinases of Mycobacterium tuberculosis. Trends Microbiol. 8:238-244. - PubMed
    1. Babu, M. M. 2003. Did the loss of sigma factors initiate pseudogene accumulation in M. leprae? Trends Microbiol. 11:59-61. - PubMed
    1. Beaucher, J., S. Rodrigue, P.-E. Jacques, I. Smith, R. Brzezinski, and L. Gaudreau. 2002. Novel Mycobacterium tuberculosis anti-σ factor antagonists can control σF activity by distinct mechanisms. Mol. Microbiol. 45:1527-1540. - PubMed

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