Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2004 Feb 15;172(4):2296-306.
doi: 10.4049/jimmunol.172.4.2296.

Reduced thymocyte development in sonic hedgehog knockout embryos

Divya K Shah  1 , Ariadne L Hager-Theodorides, Susan V Outram, Susan E Ross, Alberto Varas, Tessa Crompton
Affiliations

Reduced thymocyte development in sonic hedgehog knockout embryos

Divya K Shah et al. J Immunol. .

Abstract

The Hedgehog family of secreted intercellular signaling molecules are regulators of patterning and organogenesis during animal development. In this study we provide genetic evidence that Sonic Hedgehog (Shh) has a role in the control of murine T cell development. Analysis of Shh(-/-) mouse embryos revealed that Shh regulates fetal thymus cellularity and thymocyte differentiation. Shh is necessary for expansion of CD4(-)CD8(-) double-negative (DN) thymocytes and for efficient transition from the earliest CD44(+)CD25(-) DN population to the subsequent CD44(+)CD25(+) DN population and from DN to CD4(+)CD8(+) double-positive cells.

PubMed Disclaimer

Publication types

MeSH terms