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. 2004 Feb 6;303(5659):848-51.
doi: 10.1126/science.1090922.

TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia

Neil A Bhowmick  1 , Anna Chytil, David Plieth, Agnieszka E Gorska, Nancy Dumont, Scott Shappell, M Kay Washington, Eric G Neilson, Harold L Moses
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Free article

TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia

Neil A Bhowmick et al. Science. .
Free article

Abstract

Stromal cells can have a significant impact on the carcinogenic process in adjacent epithelia. The role of transforming growth factor-beta (TGF-beta) signaling in such epithelial-mesenchymal interactions was determined by conditional inactivation of the TGF-beta type II receptor gene in mouse fibroblasts (Tgfbr2fspKO). The loss of TGF-beta responsiveness in fibroblasts resulted in intraepithelial neoplasia in prostate and invasive squamous cell carcinoma of the forestomach, both associated with an increased abundance of stromal cells. Activation of paracrine hepatocyte growth factor (HGF) signaling was identified as one possible mechanism for stimulation of epithelial proliferation. Thus, TGF-beta signaling in fibroblasts modulates the growth and oncogenic potential of adjacent epithelia in selected tissues.

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  • Cancer. Respect thy neighbor!
    Radisky DC, Bissell MJ. Radisky DC, et al. Science. 2004 Feb 6;303(5659):775-7. doi: 10.1126/science.1094412. Science. 2004. PMID: 14764858 No abstract available.

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